Background Neonatal hyperbilirubinaemia remains one of the most common clinical
conditions requiring therapeutic intervention. Nevertheless, reliable indicators of bilirubin
toxicity are still missing. This prompted us to investigate (a) the progression of cytotoxic
events produced by increasing concentrations of bilirubin;(b) the relevance of the membrane
lipid package on bilirubin binding to erythrocytes; and (c) the reliability of chloroform
extraction compared with albumin extraction to evaluate erythrocyte‐bound bilirubin and …

Assessment of bilirubin toxicity to erythrocytes: Implication in neonatal jaundice
management. …